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Article

Trophoblast-derived IL-6 serves as an important factor for normal pregnancy by activating Stat3-mediated M2 macrophages polarization.

International immunopharmacology - 1 Jan 2021

Ding Jinli, Yang Chaogang, Cheng Yanxiang, Wang Jiayu, Zhang Sainan, Yan Sisi, He Fan, Yin Tailang, Yang Jing

Abstract excerpt

Macrophages are major components of decidual microenvironment that play an important role in human implantation and placentation. Trophoblasts which migrate into the endometrium and interplay with decidual cells, have been reported to participate in the polarization of macrophages. However, the potential mechanisms of trophoblasts modulating M2 macrophages polarization still need further exploration. Herein, we...

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PMID: 32718866
DOI: 10.1016/j.intimp.2020.106788

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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