Role of zinc transporter ZIP12 in susceptibility-weighted brain magnetic resonance imaging (MRI) phenotypes and mitochondrial function.

doi:10.1096/fj.202000772R

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Article

Role of zinc transporter ZIP12 in susceptibility-weighted brain magnetic resonance imaging (MRI) phenotypes and mitochondrial function.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2020

Strong Morgan D, Hart Matthew D, Tang Tony Z, Ojo Babajide A, Wu Lei, Nacke Mariah R, Agidew Workneh T, Hwang Hong J, Hoyt Peter R, Bettaieb Ahmed, Clarke Stephen L, Smith Brenda J, Stoecker Barbara J, Lucas Edralin A, Lin Dingbo, Chowanadisai Winyoo

Abstract excerpt

Brain zinc dysregulation is linked to many neurological disorders. However, the mechanisms regulating brain zinc homeostasis are poorly understood. We performed secondary analyses of brain MRI GWAS and exome sequencing data from adults in the UK Biobank. Coding ZIP12 polymorphisms in zinc transporter ZIP12 (SLC39A12) were associated with altered brain susceptibility weighted MRI (swMRI). Conditional and joint...

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PMID: 32716562
DOI: 10.1096/fj.202000772R

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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