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Article

Nutrigenomic profiling identifies ZIP10 (SLC39A10) as a regulator of erythroid zinc homeostasis with genetic associations to anemia risk.

Proceedings of the National Academy of Sciences of the United States of America - 24 Feb 2026

Kim Juyoung, Sun Yitang, Ye Kaixiong, Lee Jaekwon, Cousins Robert J, Ryu Moon-Suhn

Abstract excerpt

Erythroid progenitors undergo dynamic morphological changes and robust heme biosynthesis during differentiation. Zinc is essential for erythropoiesis, yet the mechanisms linking zinc availability to heme biosynthesis and anemia risk remain unclear. This study aimed to define zinc-responsive pathways in differentiating erythroid progenitors and to evaluate the translational relevance of SLC39A10 (ZIP10) genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41701827
DOI: 10.1073/pnas.2533600123
PMCID: PMC12933087

Genes

SLC39A10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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