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Article

SCN1Bβ mutations that affect their association with Kv4.3 underlie early repolarization syndrome.

Journal of cellular and molecular medicine - 1 Nov 2018

Yao Hao, Fan Jun, Cheng Yun-Jiu, Chen Xu-Miao, Ji Cheng-Cheng, Liu Li-Juan, Zheng Zi-Heng, Wu Su-Hua

Abstract excerpt

BACKGROUND: Abnormal cardiac ion channels current, including transient outward potassium current (Ito ), is associated with early repolarization syndrome (ERS). Previous studies showed that mutations in SCN1Bβ both to increase the Ito current and to decrease the sodium current. Yet its role in ERS remains unknown. OBJECTIVE: To determine the role of mutations in the SCN1Bβ subunits in ERS. METHODS: We screened...

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Identifiers

PMID: 30160358
DOI: 10.1111/jcmm.13839
PMCID: PMC6201368

Genes

KCND3

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