Article
Molecular pathogenesis of peripheral neuroblastic tumors.
Oncogene - 18 Mar 2010
Janoueix-Lerosey I, Schleiermacher G, Delattre O
Abstract excerpt
Neuroblastoma (NB) is an embryonal cancer of the sympathetic nervous system observed in early childhood, characterized by a broad spectrum of clinical behaviors, ranging from spontaneous regression to fatal outcome despite aggressive therapies. NB accounts for 8-10% of pediatric cancers and 15% of the deaths attributable to malignant conditions in children. Interestingly, NB may occur in various contexts, being...
Topics
- Anaplastic Lymphoma Kinase
- Genetic Heterogeneity
- Genetic Predisposition to Disease
- Homeodomain Proteins
- Humans
- Kaplan-Meier Estimate
- Mutation
- Neuroblastoma
- Protein-Tyrosine Kinases
- Receptor Protein-Tyrosine Kinases
- Transcription Factors