Article
Diversification of DNA-Binding Specificity by Permissive and Specificity-Switching Mutations in the ParB/Noc Protein Family.
Cell reports - 21 Jul 2020
Jalal Adam S B, Tran Ngat T, Stevenson Clare E, Chan Elliot W, Lo Rebecca, Tan Xiao, Noy Agnes, Lawson David M, Le Tung B K
Abstract excerpt
Specific interactions between proteins and DNA are essential to many biological processes. Yet, it remains unclear how the diversification in DNA-binding specificity was brought about, and the mutational paths that led to changes in specificity are unknown. Using a pair of evolutionarily related DNA-binding proteins, each with a different DNA preference (ParB [Partitioning Protein B] and Noc [Nucleoid Occlusion...
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