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Defining rules governing recognition and Fc-mediated effector functions to the HIV-1 co-receptor binding site

21 Jul 2020

Abstract excerpt

BACKGROUND: The binding of HIV-1 Envelope glycoproteins (Env) to host receptor CD4 exposes vulnerable conserved epitopes within the co-receptor binding site (CoRBS) which are required for the engagement of either CCR5 or CXCR4 co-receptor to allow HIV-1 entry. Antibodies against this region have been implicated in the protection against HIV acquisition in non-human primate (NHP) challenge studies and found to act...

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PMID: 32693837
DOI: 10.1186/s12915-020-00819-y

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