Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacological Characterization of the Mechanism of Action of R523062, a Promising Antiviral for Enterovirus D68

21 Jul 2020

Abstract excerpt

Enterovirus D68 (EV-D68) is a re-emerging virus that causes moderate to severe respiratory diseases in children. In severe cases, EV-D68 infection can lead to neurological complications called acute flaccid myelitis (AFM). There is currently no antiviral or vaccine available for EV-D68. The goal of this study is to delineate the mechanism of action of a promising antiviral drug candidate R523062 that was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA and protein synthesis mechanisms
Share to RNA regulation and disease
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32692536
DOI: 10.1021/acsinfecdis.0c00383

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacological Characterization of the Mechanism of Action of R523062, a Promising Antiviral for Enterovirus D68PMID 32692536Read ↗

Enterovirus D68 Antivirals: Past, Present, and FutureSemantic proximity Read ↗

Inhibition of enterovirus 71 by adenosine analog NITD008.Semantic proximity Read ↗

Enterovirus D68 molecular and cellular biology and pathogenesisSemantic proximity Read ↗

Identification of four neutralizing antigenic sites on the enterovirus D68 capsidSemantic proximity Read ↗

Isolating Compounds that Inhibit EV 71 VirusSemantic proximity Read ↗

New class of early-stage enterovirus inhibitors with a novel mechanism of action.Semantic proximity Read ↗

Characterization of three small molecule inhibitors of enterovirus 71 identified from screening of a library of natural products.Semantic proximity Read ↗

ADAR1p110 promotes Enterovirus D68 replication through its deaminase domain and inhibition of PKR pathwaySemantic proximity Read ↗

A Series of Adenosine Analogs as the First Efficacious Anti‐SARS‐CoV‐2 Drugs against the B.1.1.529.4 Lineage: A Preclinical Repurposing Research StudySemantic proximity Read ↗

Molecular mechanism of rhinovirus escape from the Pyrazolo[3,4-d]pyrimidine capsid-binding inhibitor OBR-5-340 via mutations distant from the binding pocket: Derivatives that brake resistance.Semantic proximity Read ↗

Identification of an Antiviral Compound from the Pandemic Response Box that Efficiently Inhibits SARS-CoV-2 Infection In VitroSemantic proximity Read ↗

Inhibition of enterovirus 71 replication and the viral 3D polymerase by aurintricarboxylic acidSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.