Article
Association of MICA polymorphism with HLA-B51 and disease severity in Korean patients with Behcet's disease.
Journal of Korean medical science - 1 Jun 2002
Park Sung-Hwan, Park Kyung-Su, Seo Young-Il, Min Do-June, Kim Wan-Uk, Kim Tai-Gyu, Cho Chul-Soo, Mok Jee-Won, Park Kyung-Sook, Kim Ho-Youn
Abstract excerpt
The HLA-B51 allele is known to be associated with Behcet's disease (BD) in many ethnic group. However, it has not yet been clarified whether the HLA-B51 gene itself is the pathogenic gene related to BD or whether it is some other gene in linkage disequlibrium with HLA-B51. Recently, the Triplet repeat (GCT/AGC) polymorphism in transmembrane region of the MHC class I chain-related A (MICA) gene was identified. To...
Topics
- Adult
- Behcet Syndrome
- Genetic Predisposition to Disease
- HLA-B Antigens
- HLA-B51 Antigen
- Histocompatibility Antigens Class I
- Humans
- Korea
- Microsatellite Repeats
- Middle Aged
- Phenotype
- Polymorphism, Genetic
- Severity of Illness Index