Constant-severe pain in chronic pancreatitis is associated with genetic loci for major depression in the NAPS2 cohort.

doi:10.1007/s00535-020-01703-w

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Article

Constant-severe pain in chronic pancreatitis is associated with genetic loci for major depression in the NAPS2 cohort.

Journal of gastroenterology - 1 Oct 2020

Dunbar Ellyn, Greer Phil J, Melhem Nadine, Alkaade Samer, Amann Stephen T, Brand Randall, Coté Gregory A, Forsmark Christopher E, Gardner Timothy B, Gelrud Andres, Guda Nalini M, LaRusch Jessica, Lewis Michele D, Machicado Jorge D, Muniraj Thiruvengadam, Papachristou Georgios I, Romagnuolo Joseph, Sandhu Bimaljit S, Sherman Stuart, Wilcox Charles M, Singh Vikesh K, Yadav Dhiraj, Whitcomb David C

Abstract excerpt

BACKGROUND: Pain is the most debilitating symptom of recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) and often requires chronic opioids or total pancreatectomy with islet autotransplantation to manage. Pain is a complex experience that can be exacerbated by depression and vice versa. Our aim was to test the hypothesis that depression-associated genes are associated with a constant-severe pain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32681239
DOI: 10.1007/s00535-020-01703-w
PMCID: PMC9124361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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