Article
Efficient export of the glucose transporter Hxt1p from the endoplasmic reticulum requires Gsf2p.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jun 1999
Sherwood P W, Carlson M
Abstract excerpt
Mutations in the GSF2 gene cause glucose starvation phenotypes in Saccharomyces cerevisiae. We have isolated the HXT1 gene, which encodes a low-affinity, high-capacity glucose transporter, as a multicopy suppressor of a gsf2 mutation. We show that gsf2 mutants accumulate Hxt1p in the endoplasmic reticulum (ER) and that Gsf2p is a 46-kDa integral membrane protein localized to the ER. gsf2 mutants also display a...
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