Alpha-1-antitrypsin (Pi) types in multiple sclerosis and lack of interaction with immunoglobulin (Gm) markers.

doi:10.1111/j.1744-313x.1988.tb00428.x

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Article

Alpha-1-antitrypsin (Pi) types in multiple sclerosis and lack of interaction with immunoglobulin (Gm) markers.

Journal of immunogenetics - 1 Jan 2000

Francis D A, Klouda P T, Brazier D M, Batchelor J R, McDonald W I, Hern J E

Abstract excerpt

Susceptibility to multiple sclerosis is thought to involve several genetic loci apart from the HLA region on chromosome 6. No Pi allotype nor phenotype was associated with the disease in 125 unrelated patients from the Grampian region of northeast Scotland. Despite a previously reported Gm-HLA association in this population there was no apparent interaction between Pi alleles and Gm type which influenced disease...

Topics

Alleles
Gene Frequency
Humans
Immunoglobulin Allotypes
Immunoglobulin G
Multiple Sclerosis
Phenotype
alpha 1-Antitrypsin

Identifiers

PMID: 3267150
DOI: 10.1111/j.1744-313x.1988.tb00428.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-3267150-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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