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Article

Genomic imprinting analyses identify maternal effects as a cause of phenotypic variability in type 1 diabetes and rheumatoid arthritis.

Scientific reports - 14 Jul 2020

Blunk Inga, Thomsen Hauke, Reinsch Norbert, Mayer Manfred, Försti Asta, Sundquist Jan, Sundquist Kristina, Hemminki Kari

Abstract excerpt

Imprinted genes, giving rise to parent-of-origin effects (POEs), have been hypothesised to affect type 1 diabetes (T1D) and rheumatoid arthritis (RA). However, maternal effects may also play a role. By using a mixed model that is able to simultaneously consider all kinds of POEs, the importance of POEs for the development of T1D and RA was investigated in a variance components analysis. The analysis was based on...

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Share to Arthritis, Rheumatoid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epigenesis, Genetic

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Source

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Identifiers

PMID: 32665606
DOI: 10.1038/s41598-020-68212-x
PMCID: PMC7360775

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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