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Article

"Gene accordions" cause genotypic and phenotypic heterogeneity in clonal populations of Staphylococcus aureus.

Nature communications - 14 Jul 2020

Belikova Darya, Jochim Angelika, Power Jeffrey, Holden Matthew T G, Heilbronner Simon

Abstract excerpt

Gene tandem amplifications are thought to drive bacterial evolution, but they are transient in the absence of selection, making their investigation challenging. Here, we analyze genomic sequences of Staphylococcus aureus USA300 isolates from the same geographical area to identify variations in gene copy number, which we confirm by long-read sequencing. We find several hotspots of variation, including the csa1...

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Identifiers

PMID: 32665571
DOI: 10.1038/s41467-020-17277-3
PMCID: PMC7360770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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