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Mutations of NRG4 Contribute to the Pathogenesis of Nonalcoholic Fatty Liver Disease and Related Metabolic Disorders.

Diabetes - 1 Oct 2021

Li Yangyang, Jin Li, Jiang Feng, Yan Jing, Lu Yan, Yang Qing, Zhang Yi, Zhang Hong, Yu Hairong, Zhang Yuemei, He Zhen, Zhang Rong, Yang Jianjun, Hu Cheng

Abstract excerpt

Neuregulin 4 (Nrg4), an adipose tissue-enriched endocrine factor, participates in adipocyte-to-hepatocyte communication, eliciting beneficial metabolic effects in nonalcoholic fatty liver disease (NAFLD). We evaluate the physiological roles of NRG4 in humans and unravel the role of NRG4 variants in the pathogenesis of NAFLD and related metabolic disorders. We identified two rare missense mutations-p.R44H and...

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PMID: 34261740
DOI: 10.2337/db21-0064

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