Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Structural basis for RIFIN-mediated activation of LILRB1 in malaria.

Nature - 1 Nov 2020

Harrison Thomas E, Mørch Alexander M, Felce James H, Sakoguchi Akihito, Reid Adam J, Arase Hisashi, Dustin Michael L, Higgins Matthew K

Abstract excerpt

The Plasmodium species that cause malaria are obligate intracellular parasites, and disease symptoms occur when these parasites replicate in human blood. Despite the risk of immune detection, the parasite delivers proteins that bind to host receptors on the cell surfaces of infected erythrocytes. In the causative parasite of the most deadly form of malaria in humans, Plasmodium falciparum, RIFINs form the largest...

Topics

Amino Acid Sequence
Animals
Antibody-Dependent Cell Cytotoxicity
Binding Sites
Histocompatibility Antigens Class I
Humans
Killer Cells, Natural
Leukocyte Immunoglobulin-like Receptor B1
Ligands
Lipid Bilayers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocyte Activation

Malaria, Falciparum

Membrane Proteins

Models, Molecular

Molecular Mimicry

Mutation

Perforin

Protozoan Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 32650338
DOI: 10.1038/s41586-020-2530-3
PMCID: PMC7116854

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural basis for RIFIN-mediated activation of LILRB1 in malaria.PMID 32650338Read ↗

Structural basis of malarial parasite RIFIN-mediated immune escape against LAIR1.Semantic proximity Read ↗

Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs.Semantic proximity Read ↗

Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptorsSemantic proximity Read ↗

Escaping the enemy’s bullets: an update on how malaria parasites evade host immune responseSemantic proximity Read ↗

The role of the reticulocyte-binding-like protein homologues ofPlasmodiumin erythrocyte sensing and invasionSemantic proximity Read ↗

Nanobodies against <i>Plasmodium</i> adhesins that block receptor engagement and malaria parasite invasionSemantic proximity Read ↗

Dynamic hinge-motion of PfRIPR revealed by malaria invasion inhibitory antibodiesSemantic proximity Read ↗

Targeting TLR/IL-1R Signalling in Human DiseasesSemantic proximity Read ↗

RIFINs are adhesins implicated in severe Plasmodium falciparum malariaSemantic proximity Read ↗

<i>Babesia divergens</i> and <i>Neospora caninum</i> apical membrane antigen 1 structures reveal selectivity and plasticity in apicomplexan parasite host cell invasionSemantic proximity Read ↗

MMV687794 blocks <i>Plasmodium falciparum</i> invasion of red blood cells by targeting a Surface-associated Lipid-Interacting Rhoptry Protein, <i>Pf</i> SLIRPSemantic proximity Read ↗

Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.