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Article

Recapitulating atherogenic flow disturbances and vascular inflammation in a perfusable 3D stenosis model.

Biofabrication - 10 Aug 2020

Menon Nishanth Venugopal, Su Chengxun, Pang Kuin Tian, Phua Zhai Juan, Tay Hui Min, Dalan Rinkoo, Wang Xiaomeng, Li King Ho Holden, Hou Han Wei

Abstract excerpt

Blood vessel narrowing and arterial occlusion are pathological hallmarks of atherosclerosis, which involves a complex interplay of perturbed hemodynamics, endothelial dysfunction and inflammatory cascade. Herein, we report a novel circular microfluidic stenosis model that recapitulates atherogenic flow-mediated endothelial dysfunction and blood-endothelial cell (EC) interactions in vitro. 2D and 3D stenosis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 32650321
DOI: 10.1088/1758-5090/aba501

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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