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Article

Interleukin-7 and interleukin-15 drive CD4+CD28null T lymphocyte expansion and function in patients with acute coronary syndrome.

Cardiovascular research - 7 Jul 2021

Bullenkamp Jessica, Mengoni Veronica, Kaur Satdip, Chhetri Ismita, Dimou Paraskevi, Astroulakis Zoë M J, Kaski Juan Carlos, Dumitriu Ingrid E

Abstract excerpt

AIMS: Inflammation has important roles in atherosclerosis. CD4+CD28null (CD28null) T cells are a specialized T lymphocyte subset that produce inflammatory cytokines and cytotoxic molecules. CD28null T cells expand preferentially in patients with acute coronary syndrome (ACS) rather than stable angina and are barely detectable in healthy subjects. Importantly, ACS patients with CD28null T-cell expansion have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32647892
DOI: 10.1093/cvr/cvaa202
PMCID: PMC8262639

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