Numerous Brugada syndrome-associated genetic variants have no effect on J-point elevation, syncope susceptibility, malignant cardiac arrhythmia, and all-cause mortality.

doi:10.1038/gim.2016.151

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Article

Numerous Brugada syndrome-associated genetic variants have no effect on J-point elevation, syncope susceptibility, malignant cardiac arrhythmia, and all-cause mortality.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 May 2017

Ghouse Jonas, Have Christian T, Skov Morten W, Andreasen Laura, Ahlberg Gustav, Nielsen Jonas B, Skaaby Tea, Olesen Søren-Peter, Grarup Niels, Linneberg Allan, Pedersen Oluf, Vestergaard Henrik, Haunsø Stig, Svendsen Jesper H, Hansen Torben, Kanters Jørgen K, Olesen Morten S

Abstract excerpt

PURPOSE: We investigated whether Brugada syndrome (BrS)-associated variants identified in the general population have an effect on J-point elevation as well as whether carriers of BrS variants were more prone to experience syncope and malignant ventricular arrhythmia and had increased mortality compared with noncarriers. METHODS: All BrS-associated variants were identified using the Human Gene Mutation Database...

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PMID: 27711072
DOI: 10.1038/gim.2016.151

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