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Article

The D2 and D3 Sublineages of Human Papilloma Virus 16-Positive Cervical Cancer in Guatemala Differ in Integration Rate and Age of Diagnosis.

Cancer research - 15 Sept 2020

Lou Hong, Boland Joseph F, Torres-Gonzalez Edmundo, Albanez Anaseidy, Zhou Weiyin, Steinberg Mia K, Diaw Lena, Mitchell Jason, Roberson David, Cullen Michael, Garland Lisa, Bass Sara, Burk Robert D, Yeager Meredith, Wentzensen Nicolas, Schiffman Mark, Freites Enrique Alvirez, Gharzouzi Eduardo, Mirabello Lisa, Dean Michael

Abstract excerpt

Human papillomavirus (HPV) 16 displays substantial sequence variation; four HPV16 lineages (A, B, C, and D) have been described as well as multiple sublineages. To identify molecular events associated with HPV16 carcinogenesis, we evaluated viral variation, the integration of HPV16, and somatic mutation in 96 cervical cancer samples from Guatemala. A total of 65% (62/96) of the samples had integrated HPV16...

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Identifiers

PMID: 32631904
DOI: 10.1158/0008-5472.CAN-20-0029
PMCID: PMC7501218

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