Article
Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders.
Nature communications - 3 Jul 2020
Seidlitz Jakob, Nadig Ajay, Liu Siyuan, Bethlehem Richard A I, Vértes Petra E, Morgan Sarah E, Váša František, Romero-Garcia Rafael, Lalonde François M, Clasen Liv S, Blumenthal Jonathan D, Paquola Casey, Bernhardt Boris, Wagstyl Konrad, Polioudakis Damon, de la Torre-Ubieta Luis, Geschwind Daniel H, Han Joan C, Lee Nancy R, Murphy Declan G, Bullmore Edward T, Raznahan Armin
Abstract excerpt
Neurodevelopmental disorders have a heritable component and are associated with region specific alterations in brain anatomy. However, it is unclear how genetic risks for neurodevelopmental disorders are translated into spatially patterned brain vulnerabilities. Here, we integrated cortical neuroimaging data from patients with neurodevelopmental disorders caused by genomic copy number variations (CNVs) and gene...
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