Article
Defective ribosomal protein gene expression alters transcription, translation, apoptosis, and oncogenic pathways in Diamond-Blackfan anemia.
Stem cells (Dayton, Ohio) - 1 Sept 2006
Gazda Hanna T, Kho Alvin T, Sanoudou Despina, Zaucha Jan M, Kohane Isaac S, Sieff Colin A, Beggs Alan H
Abstract excerpt
Diamond-Blackfan anemia (DBA) is a broad developmental disease characterized by anemia, bone marrow (BM) erythroblastopenia, and an increased incidence of malignancy. Mutations in ribosomal protein gene S19 (RPS19) are found in approximately 25% of DBA patients; however, the role of RPS19 in the pathogenesis of DBA remains unknown. Using global gene expression analysis, we compared highly purified multipotential,...
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