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Article

DNA methylation modules in airway smooth muscle are associated with asthma severity

15 Feb 2018

Abstract excerpt

Asthma is a chronic airway inflammatory disorder characterised by airway hyperresponsiveness, inflammation and remodelling, including airway smooth muscle cell (ASMC) hyperplasia and subepithelial airway fibrosis [1, 2]. ASMCs from severe asthmatics are hyperproliferative, release more pro-inflammatory cytokines and are corticosteroid-insensitive compared with those from healthy individuals and non-severe asthma...

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PMID: 29449426
DOI: 10.1183/13993003.01068-2017

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