Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induced pluripotent stem cells of patients with Tetralogy of Fallot reveal transcriptional alterations in cardiomyocyte differentiation.

Scientific reports - 2 Jul 2020

Grunert Marcel, Appelt Sandra, Schönhals Sophia, Mika Kerstin, Cui Huanhuan, Cooper Ashley, Cyganek Lukas, Guan Kaomei, Sperling Silke R

Abstract excerpt

Patient-specific induced pluripotent stem cells (ps-iPSCs) and their differentiated cell types are a powerful model system to gain insight into mechanisms driving early developmental and disease-associated regulatory networks. In this study, we use ps-iPSCs to gain insights into Tetralogy of Fallot (TOF), which represents the most common cyanotic heart defect in humans. iPSCs were generated and further...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Clone Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Germ-Line Mutation

Share to Induced Pluripotent Stem Cells

Share to Myocytes, Cardiac

Share to Tetralogy of Fallot

Source

Open in PubMed Open full text

Identifiers

PMID: 32616843
DOI: 10.1038/s41598-020-67872-z
PMCID: PMC7331606

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induced pluripotent stem cells of patients with Tetralogy of Fallot reveal transcriptional alterations in cardiomyocyte differentiation.PMID 32616843Read ↗

Sequencing of a Chinese tetralogy of Fallot cohort reveals clustering mutations in myogenic heart progenitors.Semantic proximity Read ↗

Rare and private variations in neural crest, apoptosis and sarcomere genes define the polygenic background of isolated Tetralogy of Fallot.Semantic proximity Read ↗

Single-nucleus multiomic landscape of congenital heart diseases reveals disease-specific genotypic profilesSemantic proximity Read ↗

Establishment and characterization of a human embryonic stem cell line carrying a heterozygous GATA4T280M mutation.Semantic proximity Read ↗

Human Induced Pluripotent Stem-Cell-Derived Cardiomyocytes as Models for Genetic CardiomyopathiesSemantic proximity Read ↗

Detection of Genetic Variations in Children with Tetralogy of Fallot Using Whole Exome Sequencing Technology Integrated Bioinformatics Analysis.Semantic proximity Read ↗

Harnessing human genetics and stem cells for precision cardiovascular medicineSemantic proximity Read ↗

Genetic Variants of ISL1 Gene Promoter Identified from Congenital Tetralogy of Fallot Patients Alter Cellular Function Forming Disease BasisSemantic proximity Read ↗

Inherited cardiac diseases, pluripotent stem cells, and genome editing combined—the past, present, and futureSemantic proximity Read ↗

Multiple gene variations contributed to congenital heart disease via GATA family transcriptional regulation.Semantic proximity Read ↗

Deleterious genetic variants in <i>NOTCH1</i> are a major contributor to the incidence of non-syndromic Tetralogy of FallotSemantic proximity Read ↗

Disease Modeling and Disease Gene Discovery in Cardiomyopathies: A Molecular Study of Induced Pluripotent Stem Cell Generated Cardiomyocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.