Article
Multiple gene variations contributed to congenital heart disease via GATA family transcriptional regulation.
Journal of translational medicine - 3 Apr 2017
Qian Yanyan, Xiao Deyong, Guo Xiao, Chen Hongbo, Hao Lili, Ma Xiaojing, Huang Guoying, Ma Duan, Wang Huijun
Abstract excerpt
BACKGROUND: Congenital heart disease (CHD) is a common birth defect, and most cases occur sporadically. Mutations in key genes that are responsible for cardiac development could contribute to CHD. To date, the genetic causes of CHD remain largely unknown. METHODS: In this study, twenty-nine candidate genes in CHD were sequenced in 106 patients with Tetralogy of Fallot (TOF) using target exome sequencing (TES)....
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