Article

Poison exon splicing in the human brain: a new paradigm for understanding and targeting neurological disorders

2025-06-27

Abstract excerpt

<h4>Background</h4> Poison exons (PE) are highly conserved exons whose inclusion creates premature termination codons (PTCs) and triggers nonsense-mediated decay (NMD) of the mature transcript. Despite their important role in post-transcriptional regulation, PEs remain poorly annotated due to the lack of systematic transcriptome-wide approaches. <h4>Results</h4> A comparative analysis of 957 eukaryotic transcrip...

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Literature Corpus work: aa632503-d798-5258-8234-f73df2d71fe6
DOI: 10.1101/2025.06.26.661736

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