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Article

Eukaryotic life without tQCUG: the role of Elongator-dependent tRNA modifications in Dictyostelium discoideum.

Nucleic acids research - 20 Aug 2020

Schäck Manfred A, Jablonski Kim Philipp, Gräf Stefan, Klassen Roland, Schaffrath Raffael, Kellner Stefanie, Hammann Christian

Abstract excerpt

In the Elongator-dependent modification pathway, chemical modifications are introduced at the wobble uridines at position 34 in transfer RNAs (tRNAs), which serve to optimize codon translation rates. Here, we show that this three-step modification pathway exists in Dictyostelium discoideum, model of the evolutionary superfamily Amoebozoa. Not only are previously established modifications observable by mass...

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Identifiers

PMID: 32609816
DOI: 10.1093/nar/gkaa560
PMCID: PMC7430636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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