Article
Metabolism of the Flavonol Kaempferol in Kidney Cells Liberates the B-ring to Enter Coenzyme Q Biosynthesis.
Molecules (Basel, Switzerland) - 27 Jun 2020
Fernández-Del-Río Lucía, Soubeyrand Eric, Basset Gilles J, Clarke Catherine F
Abstract excerpt
Coenzyme Q (CoQ) is an essential component of the mitochondrial electron transport chain and an important antioxidant present in all cellular membranes. CoQ deficiencies are frequent in aging and in age-related diseases, and current treatments are limited to CoQ supplementation. Strategies that rely on CoQ supplementation suffer from poor uptake and trafficking of this very hydrophobic molecule. In a previous...
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