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Article

Ocular surface ectoderm instigated by WNT inhibition and BMP4

1 Jun 2020

Abstract excerpt

We sought to elucidate how and when the ocular surface ectoderm commits to its differentiation into the corneal epithelium in eye development from human induced pluripotent stem cells (hiPSCs) under the influence of WNT signaling and the actions of BMP4. These signals are key drivers ocular surface ectodermal cell fate determination. It was discovered that secreted frizzled related protein-2 (SFRP2) and Dickkopf1...

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Share to Corneal Surgery and Treatments
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PMID: 32603880
DOI: 10.1016/j.scr.2020.101868

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