Article
GBA variants in REM sleep behavior disorder: A multicenter study.
Neurology - 25 Aug 2020
Krohn Lynne, Ruskey Jennifer A, Rudakou Uladzislau, Leveille Etienne, Asayesh Farnaz, Hu Michele T M, Arnulf Isabelle, Dauvilliers Yves, Högl Birgit, Stefani Ambra, Monaca Christelle Charley, Abril Beatriz, Plazzi Giuseppe, Antelmi Elena, Ferini-Strambi Luigi, Heidbreder Anna, Boeve Bradley F, Espay Alberto J, De Cock Valérie Cochen, Mollenhauer Brit, Sixel-Döring Friederike, Trenkwalder Claudia, Sonka Karel, Kemlink David, Figorilli Michela, Puligheddu Monica, Dijkstra Femke, Viaene Mineke, Oertel Wolfgang, Toffoli Marco, Gigli Gian Luigi, Valente Mariarosaria, Gagnon Jean-François, Desautels Alex, Montplaisir Jacques Y, Postuma Ronald B, Rouleau Guy A, Gan-Or Ziv
Abstract excerpt
OBJECTIVE: To study the role of GBA variants in the risk for isolated REM sleep behavior disorder (iRBD) and conversion to overt neurodegeneration. METHODS: A total of 4,147 individuals were included: 1,061 patients with iRBD and 3,086 controls. GBA was fully sequenced using molecular inversion probes and Sanger sequencing. We analyzed the effects of GBA variants on the risk of iRBD, age at onset (AAO), and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.