Article
Cancer Cell Invasion of Mammary Organoids with Basal-In Phenotype.
Advanced healthcare materials - 1 Feb 2021
Parigoris Eric, Lee Soojung, Mertz David, Turner Madeleine, Liu Amy Y, Sentosa Jason, Djomehri Sabra, Chang Hao Chen, Luker Kathryn, Luker Gary, Kleer Celina G, Takayama Shuichi
Abstract excerpt
This paper describes mammary organoids with a basal-in phenotype where the basement membrane is located on the interior surface of the organoid. A key materials consideration to induce this basal-in phenotype is the use of a minimal gel scaffold that the epithelial cells self-assemble around and encapsulate. When MDA-MB-231 breast cancer cells are co-cultured with epithelial cells from day 0 under these...
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