Article
Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia.
Cell reports - 23 Jun 2020
Di Nardo Alessia, Lenoël Isadora, Winden Kellen D, Rühmkorf Alina, Modi Meera E, Barrett Lee, Ercan-Herbst Ebru, Venugopal Pooja, Behne Robert, Lopes Carla A M, Kleiman Robin J, Bettencourt-Dias Mónica, Sahin Mustafa
Abstract excerpt
Tuberous sclerosis complex (TSC) is a neurogenetic disorder that leads to elevated mechanistic targeting of rapamycin complex 1 (mTORC1) activity. Cilia can be affected by mTORC1 signaling, and ciliary deficits are associated with neurodevelopmental disorders. Here, we examine whether neuronal cilia are affected in TSC. We show that cortical tubers from TSC patients and mutant mouse brains have fewer cilia. Using...
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