Regulable neural progenitor-specific <i>Tsc1</i> loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex

Abstract excerpt

Tuberous sclerosis complex (TSC) is a multiorgan genetic disease in which brain involvement causes epilepsy, intellectual disability, and autism. The hallmark pathological finding in TSC is the cerebral cortical tuber and its unique constituent, giant cells. However, an animal model that replicates giant cells has not yet been described. Here, we report that mosaic induction of Tsc1 loss in neural progenitor...

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