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Article

Tubers from patients with tuberous sclerosis complex are characterized by changes in microtubule biology through ROCK2 signalling.

The Journal of pathology - 1 Jul 2014

Ferrer Isidre, Mohan Pooja, Chen Helen, Castellsague Joan, Gómez-Baldó Laia, Carmona Marga, García Nadia, Aguilar Helena, Jiang Jihong, Skowron Margaretha, Nellist Mark, Ampuero Israel, Russi Antonio, Lázaro Conxi, Maxwell Christopher A, Pujana Miguel Angel

Abstract excerpt

Most patients with tuberous sclerosis complex (TSC) develop cortical tubers that cause severe neurological disabilities. It has been suggested that defects in neuronal differentiation and/or migration underlie the appearance of tubers. However, the precise molecular alterations remain largely unk...

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Source

Identifiers

PMID: 24604753
DOI: 10.1002/path.4343

Genes

ROCK2
TSC2
HDAC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24604753-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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