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Article

Resolvin E1 derived from eicosapentaenoic acid prevents hyperinsulinemia and hyperglycemia in a host genetic manner.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2020

Pal Anandita, Al-Shaer Abrar E, Guesdon William, Torres Maria J, Armstrong Michael, Quinn Kevin, Davis Traci, Reisdorph Nichole, Neufer P Darrell, Spangenburg Espen E, Carroll Ian, Bazinet Richard P, Halade Ganesh V, Clària Joan, Shaikh Saame Raza

Abstract excerpt

Eicosapentaenoic acid (EPA) has garnered attention after the success of the REDUCE-IT trial, which contradicted previous conclusions on EPA for cardiovascular disease risk. Here we first investigated EPA's preventative role on hyperglycemia and hyperinsulinemia. EPA ethyl esters prevented obesity-induced glucose intolerance, hyperinsulinemia, and hyperglycemia in C57BL/6J mice. Supporting NHANES analyses showed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32579292
DOI: 10.1096/fj.202000830R
PMCID: PMC7497168

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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