Article
A circular RNA map for human induced pluripotent stem cells of foetal origin.
EBioMedicine - 1 Jul 2020
Barilani Mario, Cherubini Alessandro, Peli Valeria, Polveraccio Francesca, Bollati Valentina, Guffanti Federica, Del Gobbo Alessandro, Lavazza Cristiana, Giovanelli Silvia, Elvassore Nicola, Lazzari Lorenza
Abstract excerpt
BACKGROUND: Adult skin fibroblasts represent the most common starting cell type used to generate human induced pluripotent stem cells (F-hiPSC) for clinical studies. Yet, a foetal source would offer unique advantages, primarily the absence of accumulated somatic mutations. Herein, we generated hiPSC from cord blood multipotent mesenchymal stromal cells (MSC-hiPSC) and compared them with F-hiPSC. Assessment of the...
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