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Article

Heat shock protein 90 enhances the electron transfer between the FMN and heme cofactors in neuronal nitric oxide synthase.

FEBS letters - 1 Sept 2020

Zheng Huayu, Li Jinghui, Feng Changjian

Abstract excerpt

Heat shock protein 90 (Hsp90) is a key regulator of nitric oxide synthase (NOS) in vivo. Despite its functional importance, little is known about the underlying molecular mechanism. Here, purified dimeric human Hsp90α was used to investigate whether (and if so, how) Hsp90 affects the FMN-heme interdomain electron transfer (IET) step in NOS. Hsp90α increases the IET rate for rat neuronal NOS (nNOS) in a...

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Share to Electrons
Share to Flavin Mononucleotide
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HSP90 Heat-Shock Proteins

Share to Nitric Oxide Synthase Type I

Share to Protein Conformation, alpha-Helical

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Identifiers

PMID: 32573772
DOI: 10.1002/1873-3468.13870
PMCID: PMC7722166

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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