Article
Comparative study of the stabilities of synthetic in vitro and natural ex vivo transthyretin amyloid fibrils.
The Journal of biological chemistry - 14 Aug 2020
Raimondi Sara, Mangione P Patrizia, Verona Guglielmo, Canetti Diana, Nocerino Paola, Marchese Loredana, Piccarducci Rebecca, Mondani Valentina, Faravelli Giulia, Taylor Graham W, Gillmore Julian D, Corazza Alessandra, Pepys Mark B, Giorgetti Sofia, Bellotti Vittorio
Abstract excerpt
Systemic amyloidosis caused by extracellular deposition of insoluble fibrils derived from the pathological aggregation of circulating proteins, such as transthyretin, is a severe and usually fatal condition. Elucidation of the molecular pathogenic mechanism of the disease and discovery of effective therapies still represents a challenging medical issue. The in vitro preparation of amyloid fibrils that exhibit...
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