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Article

KSHV requires vCyclin to overcome replicative senescence in primary human lymphatic endothelial cells

18 Jun 2020

Abstract excerpt

Kaposi's Sarcoma Herpesvirus (KSHV) is present in the main tumor cells of Kaposi's Sarcoma (KS), the spindle cells, which are of endothelial origin.KSHV is also associated with two B-cell lymphomas, Primary Effusion Lymphoma (PEL) and Multicentric Castleman's Disease.In KS and PEL, KSHV is primarily latent in the infected cells, expressing only a few genes.Although KSHV infection is required for KS and PEL, it is...

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PMID: 32555637
DOI: 10.1371/journal.ppat.1008634

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