Article
Major Impacts of Widespread Structural Variation on Gene Expression and Crop Improvement in Tomato.
Cell - 9 Jul 2020
Alonge Michael, Wang Xingang, Benoit Matthias, Soyk Sebastian, Pereira Lara, Zhang Lei, Suresh Hamsini, Ramakrishnan Srividya, Maumus Florian, Ciren Danielle, Levy Yuval, Harel Tom Hai, Shalev-Schlosser Gili, Amsellem Ziva, Razifard Hamid, Caicedo Ana L, Tieman Denise M, Klee Harry, Kirsche Melanie, Aganezov Sergey, Ranallo-Benavidez T Rhyker, Lemmon Zachary H, Kim Jennifer, Robitaille Gina, Kramer Melissa, Goodwin Sara, McCombie W Richard, Hutton Samuel, Van Eck Joyce, Gillis Jesse, Eshed Yuval, Sedlazeck Fritz J, van der Knaap Esther, Schatz Michael C, Lippman Zachary B
Abstract excerpt
Structural variants (SVs) underlie important crop improvement and domestication traits. However, resolving the extent, diversity, and quantitative impact of SVs has been challenging. We used long-read nanopore sequencing to capture 238,490 SVs in 100 diverse tomato lines. This panSV genome, along with 14 new reference assemblies, revealed large-scale intermixing of diverse genotypes, as well as thousands of SVs...
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