Article
Graph pangenome captures missing heritability and empowers tomato breeding.
Nature - 1 Jun 2022
Zhou Yao, Zhang Zhiyang, Bao Zhigui, Li Hongbo, Lyu Yaqing, Zan Yanjun, Wu Yaoyao, Cheng Lin, Fang Yuhan, Wu Kun, Zhang Jinzhe, Lyu Hongjun, Lin Tao, Gao Qiang, Saha Surya, Mueller Lukas, Fei Zhangjun, Städler Thomas, Xu Shizhong, Zhang Zhiwu, Speed Doug, Huang Sanwen
Abstract excerpt
Missing heritability in genome-wide association studies defines a major problem in genetic analyses of complex biological traits1,2. The solution to this problem is to identify all causal genetic variants and to measure their individual contributions3,4. Here we report a graph pangenome of tomato constructed by precisely cataloguing more than 19 million variants from 838 genomes, including 32 new reference-level...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.