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Is there any correlation among MKK4 (mitogen-activated protein kinase kinase 4) expression, clinicopathological features, and KRAS/NRAS mutation in colorectal cancer.

Expert review of molecular diagnostics - 1 Aug 2020

Dogan Mutlu, Guresci Servet, Acikgoz Yusuf, Ergun Yakup, Kos Fahriye Tugba, Bozdogan Onder, Bal Oznur

Abstract excerpt

BACKGROUND: We aimed to evaluate the correlation between MKK4 expression and clinicopathological features, KRAS/NRAS mutation in colorectal cancer. METHODS: MKK4 expression was assessed by immunoreactivity score (IRS). Staining intensity(SI) and percentage of positively stained cells (PP) were used for IRS (IRS = SI×PP). Cutoffs were explored with ROC analysis. Patients were grouped as WIR ('weak immunoreactive';...

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PMID: 32552144
DOI: 10.1080/14737159.2020.1784728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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