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Single‐cell transcriptomic atlas reveals immune and metabolism perturbation of depression in the pathogenesis of breast cancer

19 Sept 2024

Abstract excerpt

Epidemiological evidence indicates that major depressive disorder (MDD) may predispose the development and prognosis of breast cancer (BC) in females [1]. However, the mechanisms linking these phenotypes are not fully understood. Chronic stress, a hallmark of depression, has been underscored to affect anti-tumor immunity, tumor metabolic reprogramming, hormone synthesis in BC [2, 3], and increase tumor metastasis...

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PMID: 39297701
DOI: 10.1002/cac2.12603

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