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Article

Comparison of suspected Lynch syndrome patients carrying BRCA and BRCA-like variants with Lynch syndrome probands: Phenotypic characteristics and pedigree analyses.

Molecular genetics & genomic medicine - 1 Aug 2020

Xu Yun, Li Cong, Wang Zhimin, Liu Fangqi, Xu Ye

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) patients diagnosed with Lynch syndrome (LS) are recommended genetic testing. Increasing numbers of germline variants involved in homologous recombination have been identified in suspected LS patients. This study compared phenotypic the characteristics of suspected LS patients carrying BRCA and BRCA-like variants with those of LS patients. METHODS: Forty-two patients carrying...

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PMID: 32548945
DOI: 10.1002/mgg3.1359
PMCID: PMC7434599

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