Cancer risks in Lynch syndrome, Lynch-like syndrome, and familial colorectal cancer type X: a prospective cohort study.

doi:10.1186/s12885-020-06926-x

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Cancer risks in Lynch syndrome, Lynch-like syndrome, and familial colorectal cancer type X: a prospective cohort study.

BMC cancer - 24 May 2020

Bucksch Karolin, Zachariae Silke, Aretz Stefan, Büttner Reinhard, Holinski-Feder Elke, Holzapfel Stefanie, Hüneburg Robert, Kloor Matthias, von Knebel Doeberitz Magnus, Morak Monika, Möslein Gabriela, Nattermann Jacob, Perne Claudia, Rahner Nils, Schmiegel Wolff, Schulmann Karsten, Steinke-Lange Verena, Strassburg Christian P, Vangala Deepak B, Weitz Jürgen, Loeffler Markus, Engel Christoph

Abstract excerpt

BACKGROUND: Individuals with pathogenic germline variants in DNA mismatch repair (MMR) genes are at increased risk of developing colorectal, endometrial and other cancers (Lynch syndrome, LS). While previous studies have extensively described cancer risks in LS, cancer risks in individuals from families without detectable MMR gene defects despite MMR deficiency (Lynch-like syndrome, LLS), and in individuals from...

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PMID: 32448342
DOI: 10.1186/s12885-020-06926-x
PMCID: PMC7245918

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