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Frequency of extracolonic tumors in Brazilian families with Lynch syndrome: analysis of a hereditary colorectal cancer institutional registry.

Familial cancer - 1 Dec 2010

da Silva Felipe Carneiro, de Oliveira Ligia Petrolini, Santos Erika Monteiro, Nakagawa Wilson Toshihiko, Aguiar Junior Samuel, Valentin Mev Dominguez, Rossi Benedito Mauro, de Oliveira Ferreira Fábio

Abstract excerpt

Lynch syndrome (LS) is caused by inherited germline mutations in mismatch repair (MMR) genes. It is one of the commonest forms of inherited predisposition to colorectal cancer (CRC), accounting for 2-5% of all CRC. LS is characterized by early age of onset, with a tendency for multiplicity and an increased risk for extra-colonic tumors at particular sites. In this study we have evaluated the frequency of...

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PMID: 20697958
DOI: 10.1007/s10689-010-9373-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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