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Article

Endoplasmic Reticulum Associated Degradation of Spinocerebellar Ataxia-Related CD10 Cysteine Mutant.

International journal of molecular sciences - 14 Jun 2020

Kanuka Mai, Ouchi Fuka, Kato Nagisa, Katsuki Riko, Ito Saori, Miura Kohta, Hikida Masaki, Tamura Taku

Abstract excerpt

Spinocerebellar ataxia (SCA) is one of the most severe neurodegenerative diseases and is often associated with misfolded protein aggregates derived from the genetic mutation of related genes. Recently, mutations in CD10 such as C143Y have been identified as SCA type 43. CD10, also known as neprilysin or neuroendopeptidase, digests functional neuropeptides, such as amyloid beta, in the extracellular region. In...

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Identifiers

PMID: 32545905
DOI: 10.3390/ijms21124237
PMCID: PMC7352294

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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