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Article

Wnt/β-catenin–activated Ewing sarcoma cells promote the angiogenic switch

16 Jun 2020

Abstract excerpt

Wnt/β-catenin signaling is active in small subpopulations of Ewing sarcoma cells, and these cells display a more metastatic phenotype, in part due to antagonism of EWS-FLI1-dependent transcriptional activity. Importantly, these β-catenin-activated Ewing sarcoma cells also alter secretion of extracellular matrix (ECM) proteins. We thus hypothesized that, in addition to cell-autonomous mechanisms,...

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PMID: 32544094
DOI: 10.1172/jci.insight.135188

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