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Proteomics identifies a convergent innate response to infective endocarditis and extensive proteolysis in vegetation components

16 Jun 2020

Abstract excerpt

Infective endocarditis is a life-threatening infection of heart valves and adjacent structures characterized by vegetations on valves and other endocardial surfaces, with tissue destruction and risk of embolization. We used high-resolution mass spectrometry to define the proteome of staphylococcal and non-staphylococcal vegetations and Terminal Amine Isotopic Labeling of Substrates (TAILS) to define their...

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Share to Antimicrobial Resistance in Staphylococcus
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PMID: 32544089
DOI: 10.1172/jci.insight.135317

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