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Article

Neurofibromin and its inactivation of Ras are prerequisites for osteoblast functioning.

Bone - 1 May 2005

Yu X, Chen S, Potter O L, Murthy S M, Li J, Pulcini J M, Ohashi N, Winata T, Everett E T, Ingram D, Clapp W D, Hock J M

Abstract excerpt

Skeletal problems and osteoporosis occur in up to 50% affected neurofibromatosis type 1 (NF1) humans. Inactivation of neurofibromin results in deregulation of Ras signal transduction. Little is known of bone biology in humans with NF1. The goal of our work was to determine if loss-of-function of Nf1 gene was associated with altered bone homeostasis and Ras signal transduction. Because homozygous Nf1 mice are...

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PMID: 15804420
DOI: 10.1016/j.bone.2005.01.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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